Tubocurarine chloride

M03AA02

268 ° C

Soluble in water

( )- Tubocurarine chloride pentahydrate

Risk

150 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Tubocurarine is a neurotoxin. As a main component of Tubocurare it is one of the arrow poisons, which are collectively referred to as curare.

Operation

Tubocurarine competitively occupied the nicotinic acetylcholine receptors in the postsynaptic membrane. There is a blockage of ligand-gated sodium ion channels, with no depolarization is triggered. Tubocurarine paralyzes the striated muscles of the musculoskeletal system and is referred to as a non- depolarizing muscle relaxant.

Occurrence

Tubocurarine is for example found in Chondrodendron tomentosum and other plants of the genus.