Tumor metabolome

The term tumor metabolome describes the characteristic metabolic phenotype ( = the metabolome ) of tumor cells.

The transformation of normal cells into tumor cells is associated with drastic changes in the metabolism of cells.

Intensive metabolic characterizations ( metabolome analyzes) of various tumor cell lines and tumors have shown that more and set the same metabolic changes during tumorigenesis in certain metabolic parameters.

These changes in metabolism are

  • Regardless of the metabolic status of the tissue source from which the respective tumor has developed, such as liver and brain and
  • Independently of the molecular mechanisms by which tumor development was induced.

The characteristic metabolic properties of the tumor metabolome are:

  • High activities in glycolytic enzymes
  • The expression of the pyruvate kinase isoenzyme M2 type comprising ( = tumor M2-PK ) is predominantly in the dimeric form
  • Phosphometabolit high levels
  • A marked channeling of glucose carbon atoms in the synthesis processes, such as nucleic acid, amino acid and phospholipid synthesis
  • A high pyrimidine and purine de novo synthesis rate
  • A high fatty acid de novo synthesis rate
  • A low (ATP GTP): (CTP UTP ) ratio
  • A high - capacity glutaminolysis
  • The delivery of immunosuppressive agents
  • A pronounced methionine dependence

Swell

  • Mazurek S, Grimm H, Boschek CB, Vaupel P, Eigenbrodt E: Pyruvate kinase type M2: a crossroad in the tumor metabolome. Brit. J. Nutr. (2002), 87: 23-29. PMID 11895152 (English)
  • Mazurek S, Eigenbrodt E: The tumor metabolome. Anticancer Res (2003 ) 23: 1149-1154. PMID 12820363 (English)
Metabolomics Anticancer Research
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