UDP - glucose 6- dehydrogenase ( UDPGDH ) is the enzyme that catalyzes the conversion of UDP-glucose to UDP - glucuronate in all living beings. The latter is important in the human body for the biotransformation, but also serves as starting material for the synthesis of glycosaminoglycans. In plants, the reaction is an intermediate step in the biosynthesis of hemicelluloses and pectin.

Catalyzed reaction

H2O ⇔ 2NAD ⇔ 2NADH 2H

UDP - α -D - glucuronate produced from UDP- α -D-glucose. It is noteworthy that no aldehyde to carboxylic acid produced in the conversion of alcohol.