Urocanase

Urocanase (also Urocanat hydratase ) is an enzyme that is involved in the degradation of the amino acid histidine and there catalyzes the second step, the hydration of Urocanat to hydroxy - imidazole propionate. It is found in vertebrates in the liver but is also found in some bacteria and plants. Mutations in the gene can cause UROC1 Urocanasemangel the rare hereditary disease.

Catalyzed reaction

Urocanic acid (right) is converted to hydroxy- imidazole propionate (left).

Construction

Urocanase is a homodimer of 2 * 557 amino acids with a molecular mass of 61 kDa 2 *. Both sub-units each containing a NAD molecule as a solid, but not covalently bound cofactor. A subassembly consisting of a NAD -binding domain and a core domain, containing the binding site for the other subunit.

Human Genome Organisation Lyase Mineral hydration
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