Urs A. Meyer

Urs Albert Meyer ( * July 7, 1938 in Baden ) is a Swiss physician and clinical pharmacologist.

Life

Urs A. Meyer received his doctorate in 1967 at the University of Zurich for an MD and subsequently worked at the University of California, San Francisco. In 1974 he became head of the Department of Clinical Pharmacology at the University Hospital Zurich. From 1983 until his retirement in 2008 conducted research and taught Meyer Professor of Pharmacology at the Biozentrum, University of Basel and was two years chairman of the institution. He also held various positions at the WHO and the NIH, and was president of the clinical section of the Swiss National Science Foundation (SNSF ).

Work

Urs A. Meyer conducted research in the field of pharmacogenetics and personalized medicine and examined the influence of environmental and genetic factors on the effect of drugs. Meyer discovered defects in the enzymes of the heme biosynthesis as the cause of porphyria and how drugs induce acute porphyria. He identified the first gene variants in the enzymes of the cytochrome P450 system and showed that such polymorphisms are responsible for different medicinal effects. The genetic variants of the N - acetyltransferases were discovered in his laboratory. In addition, Meyer was able to enlighten how to enable drugs transcription factors such as nuclear receptors and thereby regulate the expression of metabolizing enzymes and drug transporters.

Awards

Publications (selection )

  • Urs A. Meyer, L. James beach, Manfred Doss, A. Clegg Rees, Harvey S. Marver: Intermittent acute porphyria - demonstration of a genetic defect in porphobilinogen metabolism. In: The New England Journal of Medicine. Vol 286, 1972, p 1277-1282, PMID 5024458 doi: 10.1056/NEJM197206152862401.
  • Frank J. Gonzalez, Radek C. Skodat, Shioko Kimura, Morio Umeno, Ulrich M. Zanger, Daniel W. Nebert, Harry V. Gelboin, James P. Hardwick, Urs A. Meyer: Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. In: Nature. Vol 331, No. 6155, 1988, pp. 442-446, PMID 3123997 doi: 10.1038/331442a0.
  • M. Blum, UA Meyer: Genotyping of poor metabolizers of debrisoquine by allele -specific PCR amplification. In: Lancet. Vol 336, No. 8714, 1990, ISSN 0140-6736, pp. 529-532, PMID 1975039 doi: 10.1016/0140-6736 (90) 92086- W.
  • M. Blum, A. Demierre, DM Grant, M. Home, UA Meyer: Molecular mechanism of slow acetylation of drugs and carcinogens in humans. In: Proceedings of the National Academy of Sciences of the United States of America. Vol 88, No 12, 1991, pp. 5237-5241, PMC 51847 (Free full text ), doi: 10.1073/pnas.88.12.5237.
  • UA Meyer: Pharmacogenetics - five Decades of therapeutic lessons from genetic diversity. In Nature Reviews Genetics. Vol 5, 2004, pp. 669-676, PMID 15372089, doi: 10.1038/nrg1428.
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