Spies started his career in 1985 at SSV Ulm 1846. Already as a 18- year-old he scored 17 goals in the league 1985/86 and increased with Ulm on to the 2nd Bundesliga. 1988 was followed by the re- descent into the Oberliga Baden- Württemberg. In 1990 he moved to the then second division side SC Freiburg. With 11 hits the striker on the rise of Freiburg in 1993 was instrumental in the Bundesliga and was also a key player. In the season 1994/95 Spies occurred in all 34 regular season games for use, scoring 13 goals and had thus substantial share of the UEFA Cup achievement.
After Freiburg had to compete in 1997 the transition to the second division, Spies left the club after 80 Premier League matches (20 goals) and moved to MSV Duisburg. The zebras, he completed another 86 top-flight appearances and met another 14 times. He reached the final of the DFB-Pokal 1997/98, in which his team FC Bayern Munich defeated 1-2. In 2000, he finished his career.
By 2006, Spies was sports director of VfR Aalen.