Harper became famous for her role as Rhoda Morgenstern in the two CBS sitcoms The Mary Tyler Moore and Rhoda. From 1986 to 1987, she starred in The Hogan clan with. In the original, the sitcom was called initially by her first name Valerie, which was renamed after her departure from the show in Valerie 's Family and later in The Hogan Family. She won four Emmys and a Golden Globe.
Harper is married to his second marriage to actor Tony Cacciotti, they have a daughter.