Valganciclovir

(RS )-5- amino-3- [1- hydroxymethyl -2-( S- valyloxy ) ethoxymethyl ] - 6,7- dihydro -3H- imidazo [4,5 d] pyrimidin- 7-one

J05AB14

Antivirals

Template: Infobox chemical / molecular formula search available

Valganciclovir is an antiviral agent from the group of nucleoside analogues. It is the L- Valinylester of ganciclovir and acts as Resorptionsester: during ganciclovir must be infused, Valganciclovir is well absorbed after oral administration and has a high bioavailability. After absorption Valganciclovir is converted in the body to the actually active ganciclovir. Valganciclovir is as a drug in the drug Valcyte ® (Roche ) was used for the treatment of Cytomegalievirusretinitis in AIDS patients.

Valganciclovir has as ganciclovir prodrug of the same effects and side effects such as this. These are in some cases life-threatening disorders. It is reported Neutropenia up to agranulocytosis, anemia, thrombocytopenia, diarrhea, vomiting, abdominal pain, headache, neuropathy and liver cell damage in connection with the use of valganciclovir. It should therefore only be used in life- or eyesight -threatening infections.

Stereoisomerism

Valganciclovir contains two stereocenters. In principle, it is thus four stereoisomers. The stereocenter at the valine residue is uniform ( S)- configured. Thus, the number of stereoisomers is restricts to two. These two stereoisomers are diastereoisomers with different chemical, physical and physiological properties. The commercial preparations containing the drug as a mixture of diastereomers.

Trade names

Valganciclovir is available in Germany, Austria and Switzerland under the name of Valcyte in trade.