Vincamine

• Vincaminsäuremethylester
• ( 4a1S, 12S, 13As ) -13a -ethyl -12 -hydroxy- 2,3,4 a1, 5,6,12,13,13 a- octahydro -1H- indolo [ 3,2,1 -de ] pyrido [3, 2,1- ij] [1,5] naphthyridine -12- carboxylic acid methyl ester (IUPAC)

C04AX07

Yellow crystals

Peripheral vasodilator

232 ° C

Attention

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Vincamine is a different evergreen species occurring alkaloid. It provides with a share of 25 to 65 % of the total alkaloid content, the main alkaloid of the small evergreen dar. Vincamine is also produced synthetically and is used as a drug.

Pharmacological properties

Vincamine to affect cerebral metabolism low by improve blood circulation in the brain and increases the absorption of oxygen and glucose supply.

Vincamine penetrates the blood -brain barrier and has a strong tendency to bond the Hirngewebsproteinen on. Binding to plasma proteins is 30 %. The elimination half -life is approximately 6 hours.

Clinical information

Areas of application

Vincamine is used in cerebral blood flow and brain function disorders (slight age-related brain underachievement ), circulatory disorders of the eye and inner ear, Meniere's disease. A therapeutic benefit for brain disorders is considered to be insufficient.

Side effects

As side effects may include gastrointestinal disturbances, hypotension, arrhythmia, restlessness, dry mouth can be specified.

Other Information

Vincaminhaltige finished product ( Pervincamin ® retard, etc.) are no longer in Germany since 2005 in the market, due to the extinction of the implied authorization. In Switzerland Oxygeron ® is approved.

Vincamine is a monoterpene indole alkaloid from Eburnamin - type. It is next to vincristine, vinblastine and vindoline to the vinca alkaloids.

Vincamine is the starting material for the synthesis of vinpocetine.