Vorinostat

IUPAC: N-hydroxy- N'- phenyloctandiamid

L01XX38

Cytostatic

159 to 160.5 ° C

Template: Infobox chemical / molecular formula search available

Vorinostat (trade name in the United States: Zolinza ) is an aromatic chemical compound from the group of hydroxamic acids is used as orally is to be applied drug for histone deacetylase inhibition. It is approved for the treatment of advanced, refractory, cutaneous T-cell lymphoma. More recent clinical studies concerning the effects of vorinostat with HIV, cancer and other cancers as well as in combination therapies for solid tumors.

Pharmacology

Histones provide the protein component of chromatin acetylation and deacetylation dar. means of the histones regulates transcription of the DNA. Inhibition of histone deacetylase has a hyperacetylation of histones result. This may, inter alia, the cancer cells lead to a controlled cell death ( apoptosis).