- OMIM: 607102
- UniProt: P19544
As Wilms tumor protein ( WT) refers to a protein in vertebrates, which controls the activity of other genes as a transcription factor. The WT protein can have both activating as well as repressing effect. WTP is expressed primarily in the kidney and in a part of the blood-forming cells.
The corresponding gene, the Wilms ' tumor suppressor gene (WT1 ) lies with the people on the band 13 of the short arm of chromosome 11
Mutations in the WT1 gene cause Wilms tumors (named after the surgeon Max Wilms ), a kidney tumor that occurs with a frequency of about 1 in 100,000 in children aged 2 to 4 years. Furthermore, WT1 mutations for Frasier syndrome, Denys - Drash lead to the syndrome, for Meacham syndrome or hypospadias.