Zimelidine

  • Zimeldin
  • (Z ) -3 - ( 4'- bromophenyl ) -3 - ( 3'' - pyridyl)- dimethylallylamine
  • (Z ) -3 - [ 1 - (p -bromophenyl ) -3 - ( dimethylamino) propenyl ] pyridine
  • (Z ) -3 - ( 4-bromophenyl )-N, N- dimethyl-3- pyridin-3- ylprop -2 -en- 1-amine (IUPAC)

N06AB02

Antidepressant

Serotonin reuptake inhibitors

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The drug zimelidine (trade name: Normud ®, Zelmid ® ) was one of the first selective serotonin reuptake inhibitor (SSRI), which came on the market as an antidepressant. It was withdrawn in 1983 because it led to immunotoxic damage ( " Zimelidine Syndrome" ) and cases of Guillain -Barré syndrome.

Chemically, it involves a bromine-containing Pyridylallylamin.

Pharmacological properties

Zimelidine is a stronger serotonin reuptake inhibitors as clomipramine, the reuptake of norepinephrine is in this drug less pronounced than in the imipramine.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Active ingredient
836722
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