11β-hydroxysteroid dehydrogenase type 1

11β -hydroxysteroid dehydrogenase (11- DH ) are called eukaryotes enzymes that dehydrate steroids in a hydroxyl group at 11- position to a keto group. Especially 11 -DH 1 isoform catalyzes the conversion of cortisone to cortisol ( and vice versa), and plays a role in the regulation of the cortisone type. Is a membrane protein of the endoplasmic reticulum, which is mainly produced in the liver in humans. Mutations in the HSD11B1 gene are responsible for the so-called AME syndrome, a form of hyperandrogenism and rare genetic disease.

Catalyzed reaction

NADP NADPH / H

Cortisol is dehydrogenated to cortisone. The type II isoform used nicotinamide adenine dinucleotide (NAD ) as a cofactor.

One of the known inhibitors of this reaction is 18alpha - glycyrrhetinic acid, which is contained in licorice. A study from 2014 found that epigallocatechin gallate Green tea also inhibits this reaction and thereby possibly could explain parts of the health benefits of green tea.

Human Genome Organisation Digital Object Identifier
10128
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