24-dehydrocholesterol reductase

The sterol Δ24 reductase (also: 24 -dehydrocholesterol reductase), the enzyme which catalyzes the hydrogenation of sterols at the 24 double bond. The reaction takes place in all eukaryotes with the biosynthesis of cholesterol. The enzyme is localized in the membrane of the Golgi apparatus and the endoplasmic reticulum. In humans, there is produced mainly in the brain and adrenal glands but also in the liver, lung, spleen, prostate, and spine. Mutations in DHCR24 gene responsible for a rare hereditary disease Desmosterolosis.

Catalyzed reaction

NADPH / H ⇔ NADP

5α - cholesta -7 ,24 -dien- 3β -ol is hydrogenated to lathosterol.

NADPH / H ⇔ NADP

Desmosterol is hydrogenated to cholesterol.

Human Genome Organisation
748783
de