ATP citrate lyase

ATP citrate lyase (also ATP-citrate synthase) is the enzyme which transfers an acetyl group of citrate in the cytosol of eukaryotic cells to coenzyme A, as a result, inter alia, acetyl -CoA. This is the second reaction step in the citrate shuttle which is necessary to the herauszubefördern produced in glycolysis acetyl- CoA from the mitochondria. These processes are part of the energy metabolism in all eukaryotes.

The generated acetyl -CoA is the starting material for which takes place in the cytosol lipogenesis.

Hypocitraturie is a cause of kidney stones and may have an excessive activity of ATP - citrate lyase in urine leukocytes as a cause, as determined in a Thai study. Change in diet or potassium supplementation are potential therapies. ATP citrate lyase is a potential target for combating cancer.

Catalyzed reaction

CoA -SH ATP ⇒ ⇒ ADP Pi

Acetyl is transferred under ATP consumption of citrate on CoA: it arises oxaloacetate and acetyl -CoA.

Human Genome Organisation Transferase Cancer Cell (journal) Digital Object Identifier Cancer Research (journal)
86166
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