Basigin

Basigin (also: extracellular matrix metalloproteinase inducer, EMMPRIN short ) is a glycoprotein in the cell membrane of epithelial cells of vertebrates. It exerts functions, among others, in carbohydrate metabolism and in signal transduction of the immune system. Basigin carries an immunoglobulin (Ig ) protein domain and is determinant of the Ok blood group system. In humans, it is expressed mainly in the vascular epithelium and in malignant gliomas.

Basigin is responsible for the localization of monocarboxylate transporters MCT1, MCT4 and MCT12, their subsequent transport activity is impossible without binding to Basigin. Basigin is therefore indispensable for the exchange of lactate between the cells.

Use the Ig domain binds Basigin one cell to an adjacent cell Basigin and acts as a cell adhesion molecule. Basigin continues to bind integrins, cyclophilins, caveolin -1 and annexin II Its cytosolic domain induces the expression of matrix metalloproteinases (MMP ) and is therefore part of angiogenesis, Zellsprossung, energy metabolism, cell migration and cell motility.

Protein isoform Human Genome Organisation Blood type Digital Object Identifier
107024
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