Brinzolamide

• (4R )-4- ethylamino -2 -(3- methoxypropyl) - 1,1- dioxo -3 ,4- dihydrothieno [4,5- e] thiazine -6 -sulfonamide
• (R )-4- ethylamino -2 -(3- methoxypropyl) - 1,1- dioxo -3 ,4- dihydrothieno [4,5- e] thiazine -6 -sulfonamide

S01EC04

Carbonic anhydrase inhibitors

131 ° C.

Soluble in methanol and ethanol

Template: Infobox chemical / molecular formula search available

Brinzolamide is a sulfur-and nitrogen-containing heterocyclic chemical compound derived from thiophene. Because of their effectiveness as a carbonic anhydrase inhibitor it is used as a drug in the eye drops for the lowering of intraocular pressure.

A structurally related and similar -acting drug is dorzolamide.

Properties

Brinzolamide is a white powder that is insoluble in water but dissolves well in ethanol and methanol. The water-insoluble substance is administered in the form of eye drops suspension.

Clinical trials

The effectiveness of brinzolamide as a finished product Azopt was tested in clinical trials ( in parallel with the like dorzolamide ) in patients with glaucoma and elevated intraocular pressure ( 23 mmHg). Here, the preparation could reduce the pressure to 17 to 22 % in 1% dosage. The results with dorzolamide in 2% dosage amounted to a pressure reduction 13-22 %.

Side effects

After application to the eye, the active substance reaches the systemic circulation. Very common to common side effects include: taste perversion ( bitter or unusual taste), headache, temporary blurred vision after instillation for a period of several seconds to several minutes, ocular irritation, ocular hyperemia (foreign body sensation in the eye ).

Trade names

Azopt (D, A, CH)

Azarga (D, A, CH)