Cefpodoxime

(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyimino-acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

J01DD13

β -lactam antibiotics ( Cephalosporin 3rd generation)

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Cefpodoxime is an antibiotic from the group of third generation cephalosporins and is administered orally ( Oralcephalosporin ).

Application

Cefpodoxime is used to treat infections

• Of the sinuses,
• Pharynx and tonsillitis,
• Respiratory: acute bronchitis and pneumonia,
• Of the urinary tract ( uncomplicated ), bladder and kidney infection,
• Of the skin and soft tissues,
• The urethra in uncomplicated gonorrhea.

It also finds use as oral continuation therapy when intravenous cephalosporins are no longer necessary for continued treatment. The antibiotic is also in veterinary use.

From the Paul Ehrlich Society, it is recommended as a drug of choice for treatment of acute otitis media, acute sinusitis, and exacerbation of chronic bronchitis.

Spectrum of activity

Cefpodoxime is active against most gram-positive and gram-negative organisms.

Moderately to well- sensitive Staphylococcus aureus (methicillin -susceptible). Other susceptible organisms are Streptococcus pneumoniae, group B streptococci (Streptococcus agalactiae ), Streptococcus pyogenes, Haemophilus influenzae, Moraxella catarrhalis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and other enterobacteria.

Inherently resistant, for example, Pseudomonas aeruginosa, enterococci, Bacteroides fragilis, and Proteus vulgaris. Some germs can be insensitive by an acquired antibiotic resistance against cefpodoxime, such as Morganella morganii, Citrobacter spp. and Enterobacter spp.

Application

Cefpodoxime is administered as a prodrug cefpodoxime proxetil oral modification.