Cromoglicic acid
- IUPAC: 5,5 '- ( 2-hydroxy trimethylenedioxy ) to ( 4-oxo- 4H-1- benzopyran-2 -carboxylic acid)
- Latin: Acidum cromoglicicum
- DSCG (disodium cromoglycate - )
- S01GX01
- R01AC01
- A07EB01
- R03BC01
- D11AX17
White crystalline solid
Allergies
241 ° C ( decomposition)
1.1
Very poor in water ( 210 mg · l-1 at 25 ° C)
Attention
> 2150 mg · kg -1 ( LD50, rat, oral)
Template: Infobox chemical / molecular formula search available
Cromolyn sodium ( cromoglycate ) is a drug that is used in the treatment of and prevention of allergic diseases using. Cromolyn sodium is not absorbed enterally, so that it can only be applied locally. It is used in the following forms: Eye and nose drops, nasal sprays, capsules for inhalation and inhalation sprays.
The cromolyn sodium is the first synthetically produced substance that was applied against the mechanisms of inflammation in allergic bronchial asthma and allergy. Natural model for the chemical structure of cromolyn sodium are isolated from umbellifers furocoumarin - relatives such as khellin or Khellol.
Together with nedocromil part of cromolyn sodium to a group of medicines Cromones.
Chemical Properties
For the manufacture of pharmaceutical products, the disodium salt of cromolyn sodium is due to better solubility ( sodium cromoglycate (Ph. Eur ) ) was used.
Pharmacology
Cromolyn inhibits activated mast cells, the chloride channels and therefore the release of inflammatory mediators, such as histamine. Histamine plays an important role in allergic reaction. Used prophylactically prevent cromolyn and nedocromil both the immediate and delayed reaction. The cromolyn sodium has a very short half-life ( 60 - 90 minutes in Pulmonary recording ) can be applied and therefore must be fully effective deployment at least 4 times per day.
Areas of application
The cromolyn may be prophylactic in allergic bronchial asthma, allergic rhinitis ( hay fever) and allergic conjunctivitis (eye inflammation) are applied. It is well tolerated even with long- term use.
Cromolyn sodium inhalation is used in fixed combination with reproterol, a drug that acts to widen bronchi and eliminates the shortness of breath. It summarizes the anti-inflammatory activity and rapid relief from dyspnea in a medicament.
Side effects
In some cases, it may lead to local irritation symptoms, such as cough and hoarseness. In very rare cases, can be induced by cromolyn an asthma attack.
Trade names
- Monopreparations
- Combination preparations