Dicoumarol

• Dicoumarol
• 3,3 '- methylenebis (4- hydroxycoumarin )
• Melitoxin
• Dufalon
• Dicoumarin

B01AA01

Colorless, slightly bitter-tasting crystals

Anticoagulants

Vitamin K antagonist

287-293 ° C

Soluble in aqueous and organic solutions, benzene, and chloroform

Risk

Template: Infobox chemical / molecular formula search available

Dicumarol or dicoumarol (formerly Melitoxin ) called, is the international non-proprietary name of the chemical compound 3,3 '- methylenebis (4- hydroxycoumarin ); Dicumarol belongs to the group of 4- hydroxycoumarins.

• 2.1 Mechanism of action ( pharmacodynamics )
• 2.2 Absorption and distribution in the body ( pharmacokinetics )

Clinical information

Areas of application (indications )

It is used for the controlled anticoagulation, for example in the treatment or prevention in a tendency to thrombotic diseases. As rodenticide in rodent control, it causes severe bleeding and tissue destruction.

Adverse effects (side effects)

Possible side effects of dicumarol are occurring bleeding and hematoma due to its inhibition of blood coagulation.

Pharmacological properties

Mechanism of action ( pharmacodynamics )

It exerts its anticoagulant effect by inhibiting the enzymatic reduction of vitamin K. It works just like other coumarin derivatives.

Uptake and distribution in the body ( pharmacokinetics )

Dicumarol is taken orally and is finally largely absorbed by the intestine. In the bloodstream binds and alters it, the proteins of the blood plasma; Finally, it is reduced again by the liver.

History

It was the first time in 1938 from fermented sweet clover ( Melilotus alba ) was isolated. Dicumarol is responsible for a disease occurring in North America in cattle that receive the drug from uneaten sweet clover and fermentation in the rumen.