Diiodotyrosine

• 3,5-diiodo -L-tyrosine
• (S )-2- amino-3- (4-hydroxy -3 ,5- diiodphenyl ) propanoic acid

H03BX01

Crystalline needles

Other antithyroid

Fixed

185 ° C ( decomposition)

Poorly in water ( 617 mg · l-1 at 20 ° C)

Attention

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Diiodotyrosine (DIT ), outdated and diiodotyrosine ( DJT ), is a non- proteinogenic amino acid, which arises from the proteinogenic amino acid L- tyrosine by iodination. It is inside the human body, the precursor of thyroid hormones triiodothyronine (T3) and thyroxine ( T4).

Biological Significance

→ Main article: Thyroid hormones - formation and release

Biosynthesis (Human)

Diiodotyrosine in the thyroid gland is formed from L-tyrosine and iodide. The L- tyrosine is present here in the form of bound to thyroglobulin tyrosyl residues and the iodide by the enzyme thyroid peroxidase (TPO ) bound to the tyrosyl residues; initially formed by binding an iodine atom Monoiodtyrosin (MIT), by binding of another iodine atom then diiodotyrosine. Since the TPO contains heme as a prosthetic group, the synthesis of MIT and DIT ( and consequently the thyroid hormones) may be limited by a lack of iron.

Hormone precursor (Human)

Diiodotyrosine is in humans, the precursor of thyroid hormone L- thyroxine ( T4) and one of the precursors of the thyroid hormone triiodothyronine (T3).

Use

Diiodotyrosine is used as medicine for thyroid disease ( anti-thyroid ). In addition, there is a thermal hysteresis protein inhibitors.