Famciclovir

2 - [ 2 - (2 -amino -9H -purin- 9-yl) ethyl] - 1,3- propanediyl diacetate

  • J05AB09
  • S01AD07

Virostatikum

102-104 ° C

Template: Infobox chemical / molecular formula search available

Famciclovir is an analogue of the nucleic base and 2 -aminopurine is used as an antiviral agent against herpes viruses mainly.

Chemistry

Famciclovir is the diacetyl derivative of penciclovir after oral administration which could not achieve sufficient bioavailability. This made the development of a substance required with better pharmacokinetics.

Pharmacology

Famciclovir is a prodrug of penciclovir which is metabolized after oral administration and is converted to penciclovir by deacetylation and subsequent oxidation.

Application

The active ingredient is used as Rezidivanz for the treatment of genital herpes and for early treatment of acute herpes zoster ( " shingles "). In combination with lamivudine Famciclovir is also used in chronic hepatitis B infection.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Structural analog 2-Aminopurine Recidivism (medicine)
325810
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