Florfenicol

2,2-dichloro- N-(( 1R, 2S) -3-fluoro -1-hydroxy - 1 - (4 - (methylsulfonyl ) phenyl ) propan- 2-yl) - ethanamid

QJ01BA90, QJ51BA90

Antibiotic

100 mg · kg -1 ( LD50, mouse, i.v.)

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Florfenicol is a chlorine - and fluorine - containing chemical compound, one of the classes of aromatics and sulfones. It's like the related thiamphenicol a synthetic analogue of occurring in bacteria chloramphenicol. The antibiotic is used in veterinary medicine.

Features and Effects

Florfenicol is a little in water, readily soluble in lipids substance. It is a solution for injection (300 mg / ml solution) intramuscularly or subcutaneously against infections of the respiratory tract of animals mainly used in propylene glycol. The fabric is a broad spectrum antibiotic with activity against gram-positive and gram-negative bacteria. Absorption is slow but complete, with a bioavailability of 78 % after intramuscular injection. The half-life is depending on the recording between 2.65 (intravenously) and 18 hours ( intramuscular).

Florfenicol inhibits protein synthesis in bacteria, but also eukaryotic cells, wherein a binding to the peptidyl in ribosomes. The resistance situation is judged to be very good.

Adverse effects

Rarely, at the injection site on local swelling, often fully reversible after weeks. In cattle, a reduced feed intake was observed, but disappeared after the end of treatment. Pigs showed transient diarrhea, inflammation of the anus and edema after completion of treatment.