Fumarase

  • CAS Number: 9032-88-6

Fumarase (more precisely, fumarate hydratase ) are called enzymes that catalyze the addition of water to fumarate to L- malate or the corresponding reverse reaction. This reaction is indispensable in the citric acid cycle.

There are two different classes of Fumarasen: Fumarasen I are bacterial iron- cluster -containing, heat-labile proteins, while Fumarasen II are present in prokaryotes and eukaryotes, do not require any metal ions for their catalytic action and are much more stable. Fumarasen I appear as dimer, Fumarasen II tetramer in the mitochondria. Lack of human fumarase II can be caused by mutation of the FH gene and lead to the fumaric acid Urie and tendency to fibroids.

Protein isoform Human Genome Organisation CAS registry number Lyase Addition reaction
355566
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