Glycerol-3-phosphate dehydrogenase

  • OMIM: 138420
  • UniProt: P21695

Glycerol-3 -phosphate dehydrogenase ( GPD ) are called enzymes that catalyze the hydrogenation of dihydroxyacetone phosphate ( DHAP ) to glycerol -3 -phosphate ( G3P ) and the reverse conversion. They occur in all living things.

Said reaction is in eukaryotes is essential for the hydrogen transport from the cytosol by means of the glycerol -3-phosphate shuttle in the mitochondria in the cytosol bound to NAD hydrogen through the hydrogenation NAD -dependent GPD ( EC 1.1.1.8 ) is made to dihydroxyacetone, and the resulting transmitted by this reduction glycerol -3-phosphate diffuses through the mitochondrial membrane into the mitochondrion. There, the dehydrogenating FAD -dependent GPD is localized in the inner mitochondrial membrane ( GPD2, EC 1.1.5.3 ), and transfers the hydrogen from G3P to FAD. The dihydroxyacetone phosphate formed again by this oxidation of G3P to diffuse back into the cytosol. In the mitochondrial membrane of the hydrogen from FADH2 is coenzyme Q again transferred to NAD , and the by- products, reactive oxygen species (ROS ) are produced.

In addition to functioning in the respiratory chain seems to play a role in sperm metabolism, where it is not localized in mitochondria GPD2. The expression of GPD2 is stimulated, among other things by T3 via the thyroid hormone receptor and is tissue- dependent.

Protein isoform Human Genome Organisation Coenzyme Q10 Archives of Biochemistry and Biophysics Digital Object Identifier Biochimica et Biophysica Acta
269584
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