Humphreys
- Andrew Humphreys ( politician ) ( 1821-1904 ), American politician
- Andrew Atkinson Humphreys (1810-1883), American General
- Ben Humphreys ( born 1934 ), Australian politician
- Benjamin G. Humphreys (1808-1882), American politician and general in the Confederate army
- Benjamin G. Humphreys II (1865-1923), American politician
- Bob Humphreys ( b. 1936 ), American track and field athlete
- Charles Humphreys (1714-1786), American politician
- Christine Humphreys, Baroness Humphreys ( born 1947 ), British politician of the Liberal Democrats
- David Humphreys (officer ) ( 1752-1818 ), American diplomat, businessman and man of letters, confidant of George Washington
- David Humphreys ( rugby player ) (born 1971 ), Irish rugby player
- Edward Wingfield Humphreys (1841-1892), New Zealand politician
- Frederick Humphreys (1816-1900), American homeopath
- Frederick Humphreys ( Tauzieher ) ( 1878-1954 ), British Tauzieher
- Gerry Humphreys ( footballer ) ( born 1946 ), Welsh football player
- James E. Humphreys ( born 1939 ), American mathematician
- John Humphreys (Trick technician) ( born 1955 ), American engineer trick
- John Lisseter Humphreys (1881-1929), British colonial governor
- Milton W. Humphreys (1844-1928), American classical philologist
- Parry Wayne Humphreys (1778-1839), American politician
- Paul Humphreys ( born 1960 ), British keyboardist, singer and songwriter
- Thomas Humphreys (1890-1967), a British long-distance runner
- William Jackson Humphreys (1862-1949), American physicist and meteorologist
- William Y. Humphreys (1890-1933), American politician
In the United States:
- Humphreys (California )
- Humphreys (Missouri )
- Humphreys (Oklahoma)
- Humphreys (Pennsylvania)
In New Zealand:
- Humphreys Peak, a mountain in Arizona
- Humphrey