Insulin-degrading enzyme

Insulysin (IDE) (also insulin - degrading enzyme, formerly insulinase ) is an enzyme found in bacteria and eukaryotes. IDE is to reduce several other proteins extracellularly occurring as beta -amyloid, and somatostatin in the situation in vertebrates, in addition to the protein insulin, and to make them harmless. IDE is expressed in humans in all tissue types.

Studies in Han Chinese, Germans and Muscovites suggest an association of polymorphisms in the IDE gene with the formation of a metabolic syndrome and type 2 diabetes mellitus Furthermore, low levels of expression of IDE statistically associated with the occurrence of Alzheimer 's disease. Insulysin also is a portal of entry for infection with the varicella - zoster virus.

Human Genome Organisation MEROPS Digital Object Identifier PubMed Central
413624
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