Mitotane

  • (RS ) -1,1 -dichloro-2 - (2- chlorophenyl) - 2 - (4-chlorophenyl ) ethane
  • (RS ) -2 - (o -chlorophenyl) - 2 - (p -chlorophenyl) - 1,1-dichloroethane
  • 2,4 ' -DDD
  • Choditane
  • O, p'- TDD

QL01XX23

White solid

1.39 g · cm -3

76-78 ° C

0.26 MPa (30 ° C)

In water 0.1 mg · l-1, soluble in ethanol, isooctane and carbon tetrachloride

Attention

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Mitotane is a drug that selectively inhibits cell division as a cytostatic agent in the adrenal cortex. It is used in human medicine in inoperable adrenal cortical carcinoma, in veterinary medicine for the treatment of Cushing's syndrome.

Human Medicine

In human medicine tablets with the drug mitotane for the symptomatic treatment of advanced non - operable, metastatic or recurrent adrenal cortical carcinoma are allowed. Since there are few patients with adrenal cortical carcinoma, the disease is considered rare, and the drug was on 12 June 2002 as an orphan medicinal product ( " orphan drug " ) are reported.

Veterinary Medicine

In veterinary medicine, mitotane is used to treat an overactive adrenal gland, the so-called ( Cushing's syndrome) s. The drug acts selectively cytostatic effects on the adrenal cortex and causes a decreased secretion of cortisone. Treatment with mitotane can be permanent and thus the effect of restricting the functioning of the adrenal gland. Alternatively, a short-term high-dose application to the destruction of the organ is possible to possibly triggered by Addison's disease can be treated with medication.

The exact mechanism of action of mitotane is not known. Mitotane can be used both for the treatment of primary ( adrenocortical ) and the secondary ( pituitary ) Cushings.

Due to the potential toxicity for humans precautions must be taken in dealing with mitotane, which prevent unwanted recording. This includes, in addition to the wearing of rubber gloves during application, the consistent removal of the manure produced by the animal; Pregnant women should not come in contact with treated animals.

Mitotane can also be applied for the treatment of Alopecia X.

In recent years, mitotane has been increasingly replaced by the less aggressive acting trilostane.

Others

O, p' -DDD is included in the technical DDT as a by-product with a share of about 0.1 %, its isomer p, p' -DDD has been used in the U.S. in the 1950s as an insecticide.

Trade names

  • Lysodren
CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Vapor pressure Dangerous Substances Directive (67/548/EEC) Active ingredient Adrenocortical carcinoma Cushing's syndrome Recidivism (medicine)
576007
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