Nadolol

(R, S )-cis -5-( 3-tert- butylamino -2- hydroxypropoxy ) -1,2,3,4- tetrahydronaphthalene -2 ,3 -diol (IUPAC)

C07AA12

White to off- white crystalline powder

Not cardioselective beta-blockers

124-136 ° C

Sparingly soluble in water, slightly soluble in ethanol, practically insoluble in acetone

47.1 mg · kg -1 ( LD50, mouse, i.v.)

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Nadolol is a nonselective beta-blocker with a half-life of about 20 hours. It is used for the therapy of hypertension, angina, and migraine.

Stereoisomerism

The substance contains three stereogenic centers, thus there could be theoretically eight stereoisomers. Since the two hydroxyl groups are, however, always arranged on the mutually fused cyclohexane ring of nadolol cis - position to each other, is the drug of only two pairs of enantiomers which are present as racemates. So nadolol is a mixture of four stereoisomers.