Nimodipine

2,6-dimethyl- 4-( 3-nitrophenyl) - 1,4- dihydropyridine -3 ,5 -dicarboxylic acid 3- isopropyl ester -5-( 2-methoxyethyl ) ester (IUPAC)

C08CA06

Colorless solid

Calcium antagonist

Fixed

Insoluble in water

Attention

2738 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Nimodipine (trade name: Nimotop ®, manufactured by Bayer) is a drug (calcium channel blocker ) from the group of 1,4- dihydropyridines.

By blocking calcium channels, it has a relaxing effect on vascular muscles, supposedly particularly in the brain. It is used after subarachnoid hemorrhage to prevent vasospasm (blood vessel spasms ) and thus to secure the cerebral circulation. ( Such vessel spasms can be triggered by serotonin and hemoglobin degradation products. )

Nimodipine is also admitted to age-related brain disorders ( nootropic).