Nitrendipine

IUPAC: ( R, S) -ethyl- 5-( methoxycarbonyl) - 2,6-dimethyl- 4-( 3-nitrophenyl) - 1,4- dihydropyridine -3-carboxylate

C08CA08

Antihypertensives

Calcium antagonist

158-160 ° C

Water: 77.2 mg · l-1 at 25 ° C

Attention

2540 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Nitrendipine is a drug from the group of calcium antagonists of the 1,4- dihydropyridine type. It lowers an extension of the smooth muscle of the vessels the blood pressure considerably. Therapeutically, it is used for treatment of arterial hypertension.

Mechanism of Action

Nitrendipine blocks the calcium influx into the cardiac muscle, smooth muscle, and in the excitement of education and conduction system of the heart. This leads to the heart to a reduced contractility ( negative inotropic ) and a reduced O2 consumption. On smooth muscle, it causes dilation of small arteries ( arterioles ) and thus a afterload. Nitrendipine is a dihydropyridine. In therapeutic doses is the effect of nitrendipine and other dihydropyridine calcium antagonists hardly at heart, but almost exclusively on vessels.

Indications

Nitrendipine is approved in Germany for the treatment of essential arterial hypertension and acute as Bayotensin ® for the treatment of hypertensive emergency.

Side effects

Frequently it comes to the appearance of lower leg edema, headache and flushing, as well as occasional dizziness, fatigue, and hypoesthesia.

Rare side effects include tachycardia, palpitation, nausea, bloating, diarrhea, and increased urinary frequency.

Contraindications

In cardiogenic shock, unstable angina pectoris, myocardial infarction (within the first 4 wk. ) And children ( lack of experience ) is contraindicated the administration of nitrendipine.

Trade names

Bayotensin (D), Baypress (A, CH), Jutapress (D ), numerous generics (D)

Baroprine (A), Cenipres (A), Enea (D)