Phosphogluconate dehydrogenase (decarboxylating)

6-phosphogluconate dehydrogenase ( 6PGD ) is the enzyme that converts 6-phosphogluconate to ribulose- 5-phosphate. This reaction is the third installment in the Step pentose phosphate pathway. 6PGD is found in most living things.

A possible 6PGD deficiency due to defects in the PGD gene is asymptomatic, even if less than five percent of the normal amount available to the enzyme. Bacterial 6PGD acts as an adhesin.

Catalyzed reaction

NADP NADPH / H CO2

6- phosphogluconate is dehydrated to the keto acid, which NADPH is produced. The keto acid decomposes with release of carbon dioxide to ribulose- 5-phosphate.

Pictures of Phosphogluconate dehydrogenase (decarboxylating)

Phosphogluconate dehydrogenase (decarboxylating) # Phosphogluconate dehydrogenase (decarboxylating) # Phosphogluconate dehydrogenase (decarboxylating) # Phosphogluconate dehydrogenase (decarboxylating) # Phosphogluconate dehydrogenase (decarboxylating) # Phosphogluconate dehydrogenase (decarboxylating) # Phosphogluconate dehydrogenase (decarboxylating) # Phosphogluconate dehydrogenase (decarboxylating) # Phosphogluconate dehydrogenase (decarboxylating) # Phosphogluconate dehydrogenase (decarboxylating) #
Human Genome Organisation 6-Phosphogluconic acid Ribulose 5-phosphate PROSITE Digital Object Identifier
14852
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