Polynucleotide adenylyltransferase

The poly ( A) polymerase (PAP - α ) is an enzyme that catalyzes the post-transcriptional polyadenylation of newly synthesized pre-mRNA in the nucleus of eukaryotic cells.

The human PAP - α is found in the nucleus and in the cytosol.

The activity of the PAP - α is regulated by its (de) phosphorylation and binding of other proteins, particularly CPSF and Fip1. This type of regulation is an approach to non-specific control of gene expression. Thus, the hyperphosphorylation of PAP - α in the metaphase of meiosis by mitosis - promoting factor to shut down the Translation II On the other hand dephosphorylated the Vpr protein of HIV, for example, the PAP - α and thus leads to an enhanced translation virus proteins.

Protein isoform Human Genome Organisation Nucleotidyltransferase The EMBO Journal Digital Object Identifier
655556
de