Prostaglandin F2alpha

G02AD01

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Prostaglandin F2a (or short: PGF2a ) is a tissue hormone from the group of prostaglandins. It is involved in a mammal of operations associated with the reproduction.

Prostaglandin F2a is formed by the enzyme prostaglandin F synthase PGH2 and acting through the FP receptor. In humans around birth cyclooxygenase-2 in the placenta and the amnion is induced, leading to the synthesis of PGF2a and PGE2 which excites the smooth uterine muscle contractions, or sensitized to oxytocin. Mice, which can not form a FP receptor due to a genetic defect, can not give birth. The effect of PGF2a on the FP receptors of the corpus luteum stops there, the progesterone formation and causes luteolysis.

Prostaglandin F2a ( drug name: Dinoprost ) is used in veterinary medicine to reduce the corpus luteum ( luteolysis ) and the initiation of parturition or abortion. In cattle, it is also used nachgeburtlich for emptying the uterus (womb).

It is speculated about the reversing action of prostaglandin F2a in androgenic alopecia, which is as an opponent to the suspected trigger of alopecia, the prostaglandin D2 ( GPR44 ) serve. By the prostaglandin D2, the growth phase of the hair cut in animal experiments in mice. The follicles are in the opinion of the researchers even with a bald head still present, but form by their strong reduction even at best fluff hair. Prostaglandin F2a is used among others in the field of ophthalmology, where it leads to a prolonged growth of eyelashes.