SLC25A1
- OMIM: 190315
- UniProt: P53007
Tricarboxylate carrier, or Citratcarrier (CIC, CTP ) is called the protein in the inner membrane of mitochondria, which enables the exchange of citric acid to malate or phosphoenolpyruvate ( PEP) through the mitochondrial membrane. It is a transport protein. CTP is part of the so-called citrate shuttle and gluconeogenesis, and thus essential for energy metabolism in eukaryotes. In humans it is mainly localized in the liver cells.
The catalyzed membrane transport is:
It is an antiport. This part of the transport Citratshuttle is electrically compensated by the transport of a proton by means of the pyruvate / H symporter.
This second transport is irreversible due to the potential of the inner membrane. A possible compensatory transport is obviously unknown.
The expression of CIC is regulated by epigenetic mechanisms.