SLC25A10

• OMIM: 606 794
• UniProt: Q9UBX3

The Mitochondrial carrier dicarboxylate (DIC ) ( gene: SLC25A10 ) is that protein which inter alia enables the exchange of malate with anions through the inner membrane of mitochondria. It is for the influx of malate responsible in the mitochondria and thus essential for energy metabolism in eukaryotes. In humans, DIC is highly expressed in liver and kidney.

The catalyzed membrane transport is:

It is an antiport. Dicarboxylate are possible as malate, malonate and succinate, while others may act as a phosphate anion, sulfate, sulfite or thiosulfate.