Sorbitol dehydrogenase

Sorbitol dehydrogenase (SDH) ( Gen: SORD ) is the name for enzymes that convert sorbitol to fructose. This is the second step in the Polyolweg that is used by cells to produce fructose from glucose without ATP consumption. Every living being used Sdh. In mammals, the enzyme in all tissue types is active.

There is evidence that polymorphisms in the SORD gene are associated with type 2 diabetes mellitus in Retikulopathie. Sdh inhibitors ( or aldose reductase inhibitors) may prevent the occurrence of neurological and ophthalmological problems in diabetes and are therefore of interest as potential drugs.

Structure and Function

Sdh forms a complex tetramer, which receives its special form by a network of hydrogen bonds. This mechanism has been preserved in all mammals and is essential for the function of the enzyme.

The catalyzed reaction:

NAD (P) ⇔ NAD (P) H / H

D-sorbitol is dehydrogenated to D-fructose and vice versa.

Human Genome Organisation Adenosine triphosphate Digital Object Identifier
739254
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