Sucralfate

A02BX02

White powder

Ulcustherapeutikum

130 ° C decomposition

Soluble in dilute hydrochloric acid and sodium hydroxide solution, insoluble in water and ethanol

> 12 g · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Sucralfate is an aluminum salt of sucrose sulfate.

Effect

By taking sucralfate formed a protective film of sucralfate -protein complexes that covers the gastric mucosa and a possible Ulcusgrund. Furthermore, sucralfate pepsin and bile acids bind. In addition, it has a protective effect on the mucous membrane by prostaglandin, bicarbonate and mucus formation.

Side effects

Aluminum leads to constipation.

Indication

Applies sucralfate duodenal or gastric ulcer ( " Stressulcus " ) and their prophylaxis in the treatment of duodenal ulcer. It can also be used for the treatment of reflux oesophagitis.

Interaction

In the foreground a reduced uptake of certain substances is in the stomach and / or binding of the substances in the gastrointestinal tract due to an increase of the pH value. For this reason, it is recommended to follow a period of at least 2 hours between doses of sucralfate and other substances. Interactions occur, for example with: beta-blockers, antibiotics ( such as cephalosporins, and tetracyclines gyrase inhibitors ), L- thyroxine, theophylline, vitamin B12 and digitalis.

Trade names

Sucrabest (D), Ulcogant (D, A, CH ), various generics (D, A)