Tacrine

  • Hydroaminacrin
  • 1,2,3,4- tetrahydroacridine -9 -amine ( IUPAC)
  • 321-64-2
  • 1684-40-8 (hydrochloride)
  • 7149-50-0 (hydrochloride, monohydrate)

N06DA01

Octahedral crystals

Anti-dementia drugs

Reversible inhibition of acetylcholinesterase

Soluble in water (hydrochloride)

Hydrochloride

Risk

  • 39.8 mg · kg -1 ( LD50, mouse, oral)
  • 25 mg · kg -1 ( LD50, mouse, s.c )
  • 20 mg · kg -1 ( LD50, rat, i.v.)
  • 70 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Tacrine is a reversible inhibitor of acetylcholinesterase and was approved in the U.S. as the first substance of this group for the treatment of Alzheimer 's disease (trade name: Cognex ®; Romotal ®). The drug leads to an improvement in cognitive performance. He acts indirectly parasympathomimetisch.

In approximately 50% of patients, however, showed evidence of hepatotoxicity.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Dangerous Substances Directive (67/548/EEC)
759672
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