Tadamitsu Kishimoto

Tadamitsu Kishimoto (Japanese岸 本 忠 三, Kishimoto Tadamitsu; * 1939 in Tondabayashi, Osaka Prefecture) discovered the interleukin -6, an important chemical messenger of the immune system and put through significant achievements in the field of Signaltranskuktion, ie the processing of signals in cells forth.

IL- 6 plays an important role in the communication between cells of the immune system. Dysregulation of interleukin secretion is associated with certain immune diseases and cancer. Kishimoto examined the interleukin -6, its receptor and the subsequent signal cascades ( STAT). This work contributed significantly to the understanding of general and their cytokines Effect at.

Kishimoto has not only made important contributions to basic research, but could also achieve specific clinical and therapeutic benefits, including some drugs that are used in certain immune diseases and cancer through the development of antibodies against interleukin receptors, go back to his research.

Stations

Awards and Honors

Selection of significant publications

  • K. Yamasaki, T. Taga, Y. Hirata, H. Yawata, Y. Kawanishi, B. Seed, T. Taniguchi, T. Hirano and T. Kishimoto: Cloning and expression of the human interleukin -6 ( BSF -2 / IFN beta 2 ) receptor. In: Science .. Volume 241, No. 4867, August 12, 1988, pp. 825-828.
  • S. Minamoto, K. Ikegame, K. Ueno, M. Narazaki, T. Naka, H. Yamamoto, T. Matsumoto, H. Saito, S. Hosoe and T. Kishimoto: Cloning and functional analysis of new members of STAT induced STAT inhibitor ( SSI) family: SSI -2 and SSI - third In: Biochem Biophys Res Commun. Volume 237, No. 1, August 8, 1997, pp. 79-83.
  • M. Hibi, M. Murakami, M. Saito, T. Hirano, T. Taga and T. Kishimoto: Molecular cloning and expression of an IL -6 signal transducer, gp130. In: Cell. Volume 63, No. 6, December 21, 1990, pp. 1149-57.
  • T. Hirano, K. Yasukawa, H. Harada, T. Taga, Y. Watanabe, T. Matsuda, S. Kashiwamura, K. Nakajima, K. Koyama, A. Iwamatsu et al.: Complementary DNA for a novel human interleukin (BSF -2) induces B lymphocytes to produce did immunoglobulin. In: Nature. Volume 324, No. 6092, 6th - 12th November 1986, pp. 73-76.
Asahi Prize Crafoord Prize Japan Prize Science (journal) Cell (journal)
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