Thioridazine
(RS) -10 - [2 - (1- methylpiperidin- 2-yl ) ethyl ]-2- methylsulfanylphenothiazin (IUPAC)
- C21H26N2S2 (thioridazine )
- C21H27N2S2Cl (hydrochloride)
- 50-52-2 (thioridazine )
- 130-61-0 (hydrochloride)
N05AC02
White to off- white powder
Antipsychotics
- 370.57 g · mol -1 (thioridazine )
- 407.05 g.mol -1 (hydrochloride)
- 72-74 ° C (thioridazine )
- 158-160 ° C ( hydrochloride)
230 ° C (thioridazine, 2.66 Pa)
- Insoluble in water
- Slightly soluble in dichloromethane and methanol
- Soluble in ethanol
Hydrochloride
Attention
- 995 mg · kg -1 ( LD50, Rat, oral, thioridazine )
- 385 mg · kg -1 ( LD50, Mouse, oral, thioridazine )
- 1060 mg · kg -1 ( LD50, Rat, oral, hydrochloride)
- 360 mg · kg -1 ( LD50, Mouse, oral, hydrochloride)
Template: Infobox chemical / molecular formula search available
Thioridazine is a drug from the group of neuroleptics ( antipsychotics ).
The chemical compound is one of the phenothiazines, and is used in the form of the racemate.
Thioridazine was patented in 1966 by Sandoz and was by this company under the trade name Melleril ®. At present it is still available as a generic. The drug is mainly used as better water-soluble hydrochloride or tartrate.
Because QTc prolongation (see QT syndrome) has taken the largest manufacturer Novartis Melleril ® in the U.S. and in Europe from the market.
In India, thioridazine has recently been successfully used in several small studies against extremely resistant strains of Mycobacterium tuberculosis (XDR - TB). Larger clinical trials are planned.
Pharmacological properties
Thioridazine shows a strong blockade of
- α1 -adrenoceptors
And in each case a moderate blockade of
- Dopamine D2
- Serotonin 5 -HT2A
- Histamine H1
- And muscarinic acetylcholine M1 receptor.
A similar spectrum of activity such as thioridazine has quetiapine.