Thromboxane receptor

The thromboxane receptor ( TXA2 -R ) is a membrane-bound G protein- coupled receptor in vertebrates that mediates the clumping of platelets in humans. TXA2 -R belongs to the group of prostaglandin receptors. Mutations in the gene may cause hemophilia TBXA2R.

When TXA2 -R is activated by thromboxane, it causes in conjunction with an increase of intracellular inositol triphosphate Ca2 ( Gq -coupled receptor). This results in:

  • In platelet aggregation thereof.
  • In smooth muscle contraction thereof.
Protein isoform Human Genome Organisation Smooth muscle tissue
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