Valdecoxib

4 - (5 -methyl-3 - phenylisoxazol -4-yl ) benzenesulfonamide

M01AH03

Colorless to yellowish powder

Cyclooxygenase -2 inhibitors

Soluble in methanol and ethanol

Template: Infobox chemical / molecular formula search available

Valdecoxib ( Bextra ® trade name ) is a drug from the group of cyclooxygenase -2 inhibitors ( syn. COX -2 inhibitors or coxibs ) Pfizer.

The U.S. FDA has asked Pfizer in February 2005 to take valdecoxib from the market. The reasons were:

  • Lack of long-term data on cardiovascular safety
  • It has been reported serious allergic skin reactions after the use of valdecoxib
  • Failure to demonstrate a benefit of valdecoxib compared to other NSAIDs

The European approval after suspension in 2005 now expired.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank COX-2 inhibitor Active ingredient Allergy
121702
de