3-Bromothiophene

Bromthiophene is the collective term for two isomeric chemical compounds, which are among the heterocycles.

Representation

2- Bromothiophene

In addition to 2 - Bromothiophene The direct bromination of thiophene with elemental bromine also provides significant amounts of 2,5- dibromo. If the bromination carried out with potassium bromate and bromide, is only simple substitution.

3-bromothiophene

3- Bromothiophene can of 2,3,5 - tribromothiophene, which is easily accessible by direct bromination of thiophene can be prepared by debromination with zinc dust in acetic acid.

Reactions

When 2 - Bromothiophene is treated with sodium amide in liquid ammonia, an isomerization to 3- Bromothiophene takes place.

The isomerization can be carried out with good yields even with zeolite catalysts.

Use

3- Bromothiophene is the most important starting material for the synthesis of 3-substituted thiophenes.