4-Nitropyridine-N-oxide

4- nitropyridine -1-oxide

Yellow, combustible solid

Fixed

157-160 ° C, decomposition at > 160 ° C

Practically insoluble in water

Risk

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4- nitropyridine -N-oxide is a chemical compound selected from the group of aromatic nitro compounds, and a derivative of pyridine. The substance used as a catalyst.

Production

4- nitropyridine -N-oxide can be represented by the nitration of pyridine - N-oxide in a good yield. For this purpose, pyridine -N-oxide is reacted with a mixture of sulfuric acid and nitric acid at elevated temperature.

Toxicology

4- nitropyridine -N- oxide is mainly highly toxic to birds ( LD50 oral 8 mg / kg for wild birds, 23 mg / kg in chickens and 20 mg / kg in pigeons ), while for mammals such as guinea pigs (oral 50 mg / kg), rats (107 mg / kg orally ), dogs (oral 3916 mg / kg) and pigs (oral 7208 mg / kg) higher values ​​were determined very much. Encountered symptoms were skin and eye irritation, tremors, and convulsions, as well as restrictions on size growth and lung functions.

In mice resulted in a subcutaneous injection of 1.5 mg / week for 16 weeks after 450 days in three out of ten animals sarcomas. In in vitro studies, 4- nitropyridine N-oxide was genotoxic effects on fibroblasts of mice.