Adenylosuccinate synthase

The adenylosuccinate synthase ( also according to IUBMB: IMP -aspartate ligase ) is the enzyme that catalyses the combination of IMP and aspartate to adenylosuccinate. This reaction is part of the de novo synthesis of AMP ( metabolism of purines ) in all living things. In man, as in other vertebrates, there are two in the muscles and the liver isolated isoforms are encoded by the genes and ADSSL ADSS.

Catalyzed reaction

GTP GDP Pi

IMP and aspartate are ligated with the consumption of GTP.

Protein isoform Human Genome Organisation Adenosine monophosphate PROSITE
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