Aldehyde oxidase

Aldehyde oxidase ( AOX1 ) is an enzyme found in vertebrates, which catalyzes the reduction of aldehydes. It is also known that nicotine AOX1 oxidized to cotinine. AOX1 is therefore important for the tryptophan metabolism and biotransformation. The enzyme is located in humans in the cytosol of liver cells, but also in the lungs, to find skeletal muscles, pancreas and adipose cells.

AOX1 is homologous to the xanthine dehydrogenase, with which it was confused earlier. Lack of AOX1 is a factor in the rare molybdenum cofactor deficiency. In man only one of the AOX gene produces a functional enzyme, in contrast to other vertebrate animals.

In adipocytes, AOX1 is obviously essential for adipogenesis and the secretion of adiponectin, as inferred from cell studies. In hepatocytes AOX1 is downregulated by adiponectin. Since 1 transporter co-expressed with the ABCA, leads AOX1 deficiency by ABCA1 deficiency to reduced lipid export from the cells.

Human Genome Organisation Euteleostomi ABCA 1 Digital Object Identifier FEBS Letters
42914
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