Amylin

• OMIM: 147 940

• MGI: 96382

Amylin also islet amyloid polypeptide ( IAPP ) is a peptide hormone which is (but only in one hundredth of the amount of insulin ) is formed by the β - cells of the pancreas in conjunction with insulin. When the function is inability of the pancreas (eg diabetes), it is no longer produced as insulin. It is a major component of amyloid deposits in the islets of Langerhans which can be found in type II diabetes mellitus, for example.

Function

Amylin is a member of the endocrine system and intervenes in the metabolism of carbohydrates. It complements this insulin. Although the complete function of amylin is not yet fully known, it is believed that amylin stabilizes blood sugar levels by inhibiting the release of glucagon.

Structure

The primary structure of the human peptide composed of 37 amino acids with a disulfide bond between the cysteines Cys -2 and Cys- 7th The gene is located on chromosome 12

Pharmacology

Amylin plays a role in the long-term regulation of food intake, and therefore the use is being investigated as an appetite suppressant. For this reason, perhaps its use is also possible as an agent for treatment of type 1 and 2 diabetes. Furthermore, a publication shows a positive influence in reducing osteoporosis.