Arrestin

• OMIM: 181031
• UniProt: P10523

S- arrestin is a protein that plays an important role in the processing of light stimulation in the eyes of animals Two side. It obviously limits the forwarding of the light stimulus. In the human S- arrestin is produced in the retina and pineal gland. It may represent the antigen in autoimmune uveitis. Mutations in the SAG gene can lead to Oguchi 's disease, a rare inherited form of night blindness.

S- arrestin is a critical component in the shut-off and regulation of induced by the incident light signal cascade. It connects to temporarily active rhodopsin and thus prevents further Transducinmoleküle standing in the signaling cascade are activated by rhodopsin.