Aztreonam

(Z) -2 - [( { (2- amino-4- thiazolyl) [( 2S, 3S) -2-methyl -4-oxo -1 -sulfo- 3- azetidinyl ] carbamoyl } methyleneamino ) oxy] -2 - methyl propionic acid

  • C13H17N5O8S2 ( aztreonam )
  • C13H17N5Na2O8S2 ( aztreonam disodium salt)

J01DF01

Colorless, odorless, crystalline powder

Monobactams

227 ° C ( decomposition)

  • Soluble in DMF and DMSO
  • Very poor in ethanol, in methanol bad, practically insoluble in toluene, chloroform and ethyl acetate
  • 3300 mg · kg -1 ( LD50, mouse, iv, aztreonam disodium salt)
  • 6600 mg · kg -1 ( LD50, rat, ip, aztreonam disodium salt)

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Aztreonam is a drug selected from the group of the monobactam antibiotic, which is used in the treatment of infections with Gram-negative aerobic bacteria.

Areas of application

Infections of the kidneys, the urinary tract, lower respiratory tract (including pneumonia and bronchitis), also in cystic fibrosis (as Lysinate inhalation solution Cayston ), meningitis, infections of bones and joints, skin and soft tissue of the abdomen, in the gynecology in sepsis and gonorrhea are applications of aztreonam.

Chemical structure

Aztreonam contains - as the penicillins and the cephalosporins - a β - lactam ring. However, this is - unlike the penicillins and the Cephalisporinen - not fused to a five - or six-membered Hererocyclus.

Trade names

  • Monopreparations: Azactam (A, CH, D), Cayston (A, D)
CAS registry number PubChem Anatomical Therapeutic Chemical Classification System DrugBank Dimethyl sulfoxide Intraperitoneal injection Active ingredient Annulation
94100
de